1Post-graduate Resident, Department of Pathology,
2Associate Professor, M & J Institute of Ophthalmology,
3Professor & Head, Department of Pathology, B. J. Medical College and Civil Hospital, Asarwa
*Corresponding author: Dr. Jaimin Manek, Postgraduate Resident of Pathology, B. J. Medical College and Civil Hospital, Asarwa, Ahmedabad, 380016, Gujarat, India. E-mail: jaiminmanek1@gmail.com, Phone number: +919913368866
Online published on 6 April, 2019.
Diseases of prostate gland are important source of morbidity and mortality in male patients. The spectrum of diseases consists inflammatory conditions, nodular hyperplasia, malignancy. The risk of diseases increases with age. Prostate biopsy is essentially to detect cancer and other benign conditions. Other modalities of diagnosis, comprising of radiology and prostatic biomarkers. However, biopsy with histopatho-logical examination is the gold standard for final diagnosis.
Total 200 cases of prostatic lesions from January 2018 to June 2018 including TURP chips and needle core biopsy were evaluated in this study. The received specimens were fixed in 10% neutral buffered formalin and routine paraffin processing followed by hematoxyline and eosin staining. All specimens were analysed with following parameters: type of specimen, age, medical history and s. PSA levels, histopathological examination and final diagnosis.
In study of 200 cases, most common age group was 61–70 years. The youngest patient was 45 years and oldest was of 85 years. In our study, various histopathological patterns observed where BPH is most common finding (45% cases), BPH with chronic prostatitis (10%), granulomatous prostatitis (1%), acute prostatitis (3%) and acute on chronic prostatitis (6%). Less frequent finding were BPH with basal cell hyperplasia (1%), BPH with squamous metaplasia (2%), BPH with clear cell changes (3%) and some of biopsy show only stromal tissue with hyperplasia in (4%). We reported 14 cases (7%) of adenocarcinoma prostate with application of modified Gleason grading system.
Benign lesions are more common than malignant lesions. Among the histological patterns of prostatic lesions, BPH is predominant type. It is necessary to study all prostate biopsy in order to identify premalignant lesions, proliferative activity and grade of inflammation. Histopathological diagnosis and grading plays a definitive role in the management of prostatic cancer.
TURP & Needle biopsy, Benign Prostatic Hyperplasia, Prostate Carcinoma
