International Journal of Contemporary Surgery
  • Year: 2013
  • Volume: 1
  • Issue: 1

Randomised Study of effectiveness of Dexamethasone in Reducing Post-operative Nausea and Vomiting in Laparoscopic Cholecystectomy

  • Author:
  • Deepak Chatterjee1, Satendra Kumar1, Ashutosh Niranjan2, Arati Srivastava3, Sushil Dohare4
  • Total Page Count: 4
  • DOI:
  • Page Number: 65 to 68

1Assistant Professor, General Surgery, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P.

2Professor, General Surgery, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P.

3Associate Professor, Anaesthesiology, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P.

4Associate Professor, Community Medicine, School of Medical Sciences and Research, Sharda University, Plot No. 32–34, Knowledge Park-3, Greater Noida, U.P.

Online published on 24 April, 2013.

Abstract

This study confirms the effectiveness of preoperative administration of Dexamethasone in reducing the incidence of post-operative nausea and vomiting (PONV) after laparoscopic cholecystectomy and simultaneously establishes the exact incidence.

202 patients who underwent laparoscopic cholecystectomy under general anaesthesia were studied in a randomized, double blinded, placebo-controlled study. The Test (Dexamethasone) Group (n=103) was given dexamethasone 8mg IV and the Control (Saline) Group (n=99) was given 0.9% saline 2 ml IV before transferring to the operation area. Operative and anaesthetic techniques were standardised for all patients.

Post operatively 29.1% of the patients in the Dexamethasone Group compared with 47.5% in the Saline Group reported nausea (p=0.01). The incidence of vomiting in the Dexamethasone Group was 17.5% and in the Saline Group was 38.4% (p=0.001).

It was concluded that the incidence of nausea and vomiting after laparoscopic cholecystectomy was 47.5% and 38.4% respectively and the pre-operative administration of 8mg of dexamethasone IV significantly decreased the incidence of PONV.

Keywords

Laparoscopy Cholecystectomy, PONV, Dexamethasone