1Associate Professor, Department of Obstetrics & Gynecology, Saraswathi Institute of Medical Sciences Hapur, Uttar Pradesh, India
2Assistant Professor, Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Uttar Pradesh, India
3Demonstrator, Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Uttar Pradesh, India
4Associate Professor, Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, Uttar Pradesh, India
*Corresponding author: Asha Misra, Associate Professor, Department of Obstetrics & Gynecology, Saraswathi Institute of Medical Sciences, Hapur, U.P. India. Tel: +919997853955, E-mail: ashamisra@hotmail.com
Online published on 27 March, 2014.
To evaluate the efficacy of mifepristone (RU486) alone for labour induction at term pregnancy. The study was undertaken to portray the beneficial effect of RU 486 for cervical ripening and induction of labour.
120 patients were selected after informed consent. The criteria was term (37–39) singleton pregnancy primigravida, women with IUFD, Pregnancy Induced Hypertension. Women with grandmulti parity (> 5), previous Caeserean section, severe oligohydroamnios were excluded. Statistical analysis was done using p value <0.05 was considered significant.
The significant efficacy of RU486 was observed for cervical ripening and induction of spontaneous labour. A favorable Bishop's score of >8 was observed after 48 hours of its use; and 75% women had normal delivery. There were less numbers of caesarean sections in the study group, the difference was statistically significant. Both maternal and fetal complications were less in study group.
Mifepristone (RU486) is a safe efficient and suitable agent for cervical ripening and induction of labour when given 48 hours. before labour induction.
Mifepristone, Induction, Term, Dianoprostone, C.S. (Caesarean section), P.G. (Prostaglandin)
