Department of Anaesthesiology, MVJ MC & RH Dandupalya Post Hoskote, Bangalore
*Corresponding author: Dr. Nirmala B C, Assistant Professor, Department of Anaesthesiology MVJ MC & RH Dandupalya post Hoskote, Bangalore. No191, 2nd cross 4th main Viveknagar Bangalore 560047, nirmalbc.prasad@gmail.com, Phone no 09341285491
Online published on 26 February, 2015.
To compare the clinical effects of 3.2ml of 0.5% hyperbaric bupivacaine and nalbuphine 0.8mg and 3.2ml of 0.5% hyperbaric bupivacaine and pentazocine 3mg intrathecally.
A prospective randomized controlled open study.
100 patients belonging to ASA physical status I & II of both sexes (each group 50 patients n=50) were randomly selected for the study. The time of onset of sensory and motor block, hemodynamic status, duration of analgesia, visual analogue score and adverse effects if any were compared in both the groups.
Group I patients received 3.2ml of 0.5% hyperbaric bupivacaine and nalbuphine 0.8mg intrathecally.
Group II patients received 3.2ml of 0.5% hyperbaric bupivacaine and pentazocine 3mg intrathecally.
The time of onset of sensory and motor block was significantly longer in group II than group I(P< 0.05) Hemodynamic changes did not differ in patients of either group (p >0.05).The duration of analgesia in group I was 414.80±15.10 minutes and in group II was 339.30±51.06 minutes which was statistically significant (p<0.001). The visual analogue scores were significantly less in group I at 6 hours (p<0.001), 12 hours (p<0.001), and 24 hours (p<0.001) compared to group-II. The side effects were minimal in both the groups.
Intrathecal administration of 0.8mg of nalbuphine in combination with hyperbaric bupivacaine 0.5% produces rapid onset of anesthesia, longer duration of analgesia, with good sedation and minimal side effects thus reducing post-operative analgesic requirement.
Bupivacaine, nalbuphine, pentazocine, intrathecal, lower limb and lower abdominal surgeries, duration of analgesia
