1Professor
2Lecturer, Department of OBS & Gynae, LLRM Medical College, Meerut
3Professor, Department of Pediatrics, SIMS, Hapur
4Junior Resident, Department of OBG &GYNAE, LLRM MEDICAL College, Meerut
5Associate Professor, Department of Community Medicine, SIMS, Hapur
To evaluate maternal and neonatal effects of intravenous oxytocin given to mother during labour.
Case control study in 295 pregnant women with term and post term gestation presented to labor room.
170 pregnant women were exposed to oxytocin either for induction or augmentation of labor taking care of inclusion and exclusion criteria; and 125 women in labor were in control group. Labor was monitored and pregnancy outcome in relation to maternal and fetal outcome was compared.
The mean age of case group was 25.03±2.69 yrs while in control group was 25.68±2.25 yrs. Most women in case group were having Bishop Score <6 (66.7%). Vaginal delivery occurred in 77.6% women in case group compared to control group (89.6%). Cesarean section rate was 22.3% and 10.4% in case and control group respectively. Mean delivery interval in case group was 5.31 hours and in control group was 2 hours. The most common maternal side effect were nausea and vomiting(27.8%), maternal exhaustion(7.05%), tachysystole (2.9%), while PPH occurred 12.3% in case group and 8.5% in control group. In case group 18.24% Neonates developed hyperbilirubinemia, meoconium aspiration syndrome8.25%, respiratory distress 9.28%, HIE 3.61% and 1 min APGAR score <7 in 4.7% while 6% had 5 min APGAR score <7. NICU admission rate in case and control group was 27.64% and 8.8% respectively.
Oxytocin most commonly used drug for induction and augmentation of labor is associated with adverse outcome that are dose dependent. Oxytocin must be used in low doses.
Oxytocin, Induction, Augmentation, Adverse Neonatal outcome
