Ameliorating potential of curcumin and ascorbic acid against hepatotoxicity caused by synergistic effect of heavy metals in male Albino rats

The ameliorative role of combination of curcumin and ascorbic acid (low and high doses) was determined against biochemical and histopathological changes in liver caused due to synergistic effects of heavy metals (As, Cd and Pb) present above permissible limits in drinking water for 60 and 90 days in 84 male albino rats. The histology of liver in rats treated with a mixture of low as well as high doses of heavy metals showed mild alternations after 60 days and intense damage after 90 days. The content of biochemical parameters like proteins and lipids were significantly decreased and cholesterol, phospholipids and fatty acids were significantly increased after 60 and 90 days of treatment. The rats treated with curcumin and ascorbic acid showed restoration of histological damage and content of biochemical components indicated amelioration of hepatotoxicity effectively up to 60/90 days depending upon the dose of heavy metals, curcumin and ascorbic acid.