1Department of Life Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, India
2Division of Medical Entomology, Arbovirology and Rickettsial Diseases, ICMR-RMRC NE Region, Dibrugarh, 786010, India
*Email: sirajkhanicmr@gmail.com (corresponding author): Orcid Id 0000-0002-5142-7691
Online published on 8 August, 2025.
In this article, we discuss the possible, underlying molecular and biological basis of dengue case reduction by Wolbachia-infected mosquitoes, their field releases trial, and mathematical modelling of reduction in transmission of DENV attributable to the presence of Wolbachia. This study suggests that Wolbachia-infected DENV control could reduce dengue incidences up to 40.3 to 96% in the field release sites and A laboratory-based trial reported 100% suppression when Wolbachia-infected male mosquitoes were released. Moreover, Mathematical modeling predicted promising results in dengue reduction by Wolbachia. Documented evidence in this study support Wolbachia as a novel vector control approach to limit dengue transmission.
Aedes aegypti, Dengue, Wolbachia-infected mosquitoes, Wolbachia deployment, DENV reduction, Cytoplasmic incompatibility, Insect-specific viruses, Pelo protein, Toll pathway, Mathematical modelling
