Impact Assessment of Haematotoxicity of Synthetic Pyrethroid (Cyfluthrin) on Albino Rat

Acute and sub-acute toxicity of cyfluthrin was studied on certain blood parameters of albino rat by administering oral dose to albino rat and observing them for one day for acute and 7, 14 and 21 days for sub-acute treatment. Doses were selected on the basis of LD50 values of cyfluthrinas 726mg/kg of body weight. In the investigation acute andsub-acute treatment dose of cyfluthrin was 242mg/kg and 8.64mg/kg of body weight respectively. The synthetic pyrethroid showed dose dependent toxicity with slight tremor in whole body and caused significant alterations in blood parameters, i.e. TEC (total erythrocyte count), Hb. Conc. (Haemoglobin concentration), TLC (total leukocyte count), PCV (Packed cell volume), ESR (erythrocyte sedimentation rate) of albino rat.

Keeping this in view, toxicity of cyfluthrin has been observed. Considering the paucity of information on the effect of pyrethroids on blood, it is necessary that blood pyrethroid interaction be exposed further.