Assistant Professor, Meerut College, Meerut, India
Online published on 21 November, 2017.
Acute and sub-acute toxicity of Cybil was studied on certain blood parameters of Rattus norvegicus by administering oral dose to Rattus norvegicus and observing them for one day for acute and 7, 14 and 21 days for subacute treatment. Doses were selected on the basis LD50 values (i.e LD50 of Cybil is 643mg/kg of body weight). In the investigation acute and sub-acute treatment dose of Cybil was 129 mg/kg and 6.14 mg/kg of body weight respectively. The pyrethroid (synthetic pyrethroid) showed dose dependent toxicity with slight tremor in whole body and caused significant alterations in blood parameters, i.e TEC (total erythrocyte count), Hb. Conc.(Haemoglobin concentration), TLC (total leukocyte count), PCV (Packed cell volume), ESR (erythrocyte sedimentation rate) of Rattus norvegicus.
Keeping this in view, toxicity of Cybil has been observed. Considering the paucity of information on the effect of pyrethroid on blood, it is necessary that blood pyrethroid interaction be exposed further.
Toxicity, Synthetic Pyrethroid, Cybil
