A Review on Computational Methods Used in Construction of Protein Protein Interaction Network

Analysis of Protein Protein interaction Network helps in drug discovery and to predict functionality of a target protein. An approach called in silico and various other computational methodologies made a progressive milestone in proteomics. Computational approaches and methods reduce cost, expertise and time intervals when compare with other traditional approaches such as in vivo and in vitro. In this survey different computational approaches and methods such as genomic based methods, Homology based methods and biological mining techniques were discussed with their pros and cons in the area of protein protein interactions. It altogether gives an idea on available methods to build efficient protein protein interaction network for further research.