Synthesis of N-substituted Hydroxamic Acids

A series of N-substituted hydroxamic acids, R.N(OH).C(O).R’, have been synthesized by reacting freshly prepared N-substituted hydroxylamines and acid chlorides in mixed diethyl ether and petroleum ether (boiling range 40 to 600 C) media at 0 to 50 C, and neutralizing the liberated hydrochloric acid with aqueous suspensions of sodium bicarbonate. These compounds have been prepared for analytical applications and physico-chemical studies. These are also to be examined for antibacterial, antifungieidal and antiviral activity. The melting points of these compounds are as under.

R=-C₆H₄CH₃-4, R’=-C₆H₄F-3, 99°: -C₆H₄Cl-3, 99°;-C₆H₃C_l2-2, 4, 163°;-CH₂ Cl, 123°;-(CH₂)7 CH₃, 82°;-(CH₂)8 CH₃, 86°;-(CH₂)2C₆H5, 118°;-(CH)2C₆H5, 156°;-(CH₃O)₂C₆H₃-3, 5, 130°;-C₄H₃, 131°R=-C₆H₄CH₃-3, R’=-C (CH₃)3, 105°: R=-C₆H₄Cl-4, R’=-(CH₂)14CH₃, 100°: R=-CH₂C₆H₅, R’=-C (CH₃)3, 104°: -(CH₂)₁₄CH₃, 94°: