1Chemistry Divison, Kadi Sarva Vishwavidhyalaya
2Chemistry Divison, HVHP Instiyute of PG Studies and Research, Kadi
3Microbiology Divison, HVHP instiyute of PG studies and Research, Kadi
4Chemistry Divison, Patel J.D.K Davolwala Science Collage, Borsad
Online published on 19 April, 2019.
A convenient and competent synthesis of a series of eleven new Cholic acid derivative (A-K) is described starting from Cholic acid. The invitroantimicrobial estimation of the newly synthesized Cholic acid derivative was performed against four bacterial strains i.e.two Gram-positive bacteria viz. Bacillus subtilis(MTCC 441) & Staphylococcus epidermidis(MTCC 6880), two Gram-negative bacteria viz. Escherichiacoli(MTCC 1652) & Pseudomonas aeruginosa(MTCC 424) and twofungal strains viz. Candida albicans(MTCC 227) & Aspergillus niger(MTCC 8189) by sequential dilution technique. The derivatives 2e, 2f, 2gand 2kwere found to exhibit better antibacterial activity than other tested compounds against B. S.epidermidis.
Cholic acid, HATU(1-[Bis(dimethylamino) methylene]-1H-1, 2, 3-triazolo[4, 5-b] pyridinium 3-oxid hexafluorophosphate), Antimicrobial
