Department of Pure and Applied Chemistry, University of Calabar, Calabar – Nigeria
Online published on 7 May, 2019.
Complexes of Pt(II) and Ru(II)1 ions made from a Schiff base ligand derived from 2-hydroxy-1-naphthaldehyde and 4-amino-3-mercepto-5-propyl-1,2,4-triazole were synthesized. Characterization was done on the basis of some physicochemical parameters; infrared and uv-visible spectroscopic studies. The ligand acted as a bidentate molecule coordinating through NS heteroatoms to Pt(II) ion and as a tridentate coordinating through NSO donor atoms to Ru(II) ion. The experimental data obtained were in affirmation with many documented literatures that revealed the complexes to exist as square planar and octahedral geometrical configurations for Pt(II) and Ru(II)ions respectively. The synthesized chelates were screened against some species of bacteria such as Staphylococcus aureus, Streptococcus pyrogones, and fungi such as Candida albican and Aspergillus Niger using the disc diffusion method and broth agar method. The metal complexes showed better potency as antimicrobial agents than the free ligand and even when compared to the standard, they fair better and therefore, can serve as effective drugs against these pathogens.
Ligand, bidentate, tridentates chelate, antimicrobial activities
