Synthesis of some quinoline 3-carbonitrile derivatives and their biological evaluation as cytotoxic agent

A series of 2-Amino-4-subistituted-5,67,8-tetrahydroquinoline-3-carbonitriles supported with some functionalities reported to contribute to significant chemotherapeutic potential were synthesized and evaluated for their cytotoxic activity. Ten compounds exhibited cytotoxic potential against a panel of three human tumor cell lines. Compounds 13, 14 and 17 proved to be the most active agents with a broad spectrum of cytotoxic activity. Analog 14 was considered as the most active cytotoxic agent, being about two times more active than doxorubicin against the colon HT29 carcinoma cell line.