1Assistant Professor, Department of Medicine, G.R. Medical College, Gwalior, M.P.
2Assistant Professor, Department of ENT, G.R. Medical College, Gwalior, M.P.
*Correspondence Dr. Neelima Singh “Kamla Bhawan ”Dal Bazar Tiraha, Lashkar, Gwalior-474009(M.P) Phone no-07514045929 Mobile--9977641964, Email-neelimajadon@yahoo.com
Online published on 17 August, 2016.
Aluminium phosphide poisoning continues to claim so many lives. More so the researches in this area has virtually come to a standstill, hence this study. Aluminium phosphide(ALP) is one of the most fatal poison with phosphine as the toxic factor.
1. To determine the clinical profile of Aluminium phosphide poisoning.2. To study the effect of Aluminium phosphide poisoning on myocardium.3 To study the outcome of Aluminium phosphide poisoning.
This is a prospective study conducted in patients with alleged history of aluminium phosphide ingestion. In addition to Electrcardiogram, routine biochemical examination creatinine phosphokinase (CPK-MB), SGOT, SGPT was done in all the cases. Management was mainly supportive. Adequate renal perfusion and urine output was maintained to enhance phosphine excretion. Intavenous magnesium sulphate was administered for stabilization of myocardial membrane.
30 cases were enrolled for the study. Males 23 (76.67%) outnumbered females 7(23.33%) Pain abdomen was present in 25 (83.33%).19 (63.3%) patients presented with hypotension. Renal profile was deranged in 10 (33.3%) cases. Elevated liver enzymes was observed in 16 (53.3%) cases. Raised CPK-MB levels were seen in 20 (66.6%). ECG changes were present in 28 (93.33%). Pleural effusion was noted in 4 (13.3%). Mortality was 9 (30%).
Aluminium phosphide poisoning presents with cardiovascular manifestations. Phosphine virtually affects all the organs in the body and, therefore, early identification of impending organ damage is essential to reduce morbidity and mortality.
Aluminium Phosphide, Myocardium, Phosphine
