Indian Journal of Forensic Medicine & Toxicology
  • Year: 2016
  • Volume: 10
  • Issue: 2

Application of DNA Methylation in Forensic Science: A Review

1Ph. D. Scholar, Department of Anthropology, University of Delhi, Delhi, India

2Senior Faculty, Biology, LNJN National Institute of Criminology and Forensic Science, Delhi, India

*Corresponding author: Suchita Rawat Ph. D. Scholar, Department of Anthropology, University of Delhi, Delhi 110007, India, suchitarawat1990@gmail.com

Online published on 17 August, 2016.

Abstract

DNA methylation is an epigenetic mechanism which plays a vital role in the control and regulation of gene expression. In the past few years DNA Methylation was widely investigated in Medical field to understand complex diseases, but of late there has been a surge in studies exploring its potential use in Forensic Science. The present review discusses the application of DNA methylation to decipher regularly encountered query faced by a criminalist which includes DNA authentication, Body fluid identification, paternity dispute, Ancestry, gender and age estimation and Identification of monozygotic twins. The review also gives an insight about DNA methylation limitations.

Keywords

DNA Methylation, Body fluid identification, Ancestry estimation, Age Estimation, Gender determination