Indian Journal of Forensic Medicine & Toxicology

Blunt head trauma is the leading cause of death in criminal cases. Various efforts have been made to find an alternative autopsy method to determine the cause of death. S100B level has been used as a biomarker in blunt head trauma for the living victims. The purpose of this study was to analyze the postmortem level of S100B in cerebrospinal fluid and serum particularly in determining the cause and the time of death. This experimental study used post test only group design. The treatment groups were divided into 8 groups. The samples of each group were 6 adults of Rattus novergicus variant sprague dawley. The S100B level was checked at 0 hour, 1 hour, 2 hours and 3 hours post mortem. Analysis of postmortem level of S100B in cerebrospinal fluid and serum used the general linear model repeated measure test. There is an elevation level of postmortem S100B in cerebrospinal and serum on the death due to blunt head trauma and acute ketamine poisoning. There is no significant difference of postmortem S100B level in cerebrospinal fluid and serum in the case of death due to blunt head trauma and acute ketamine poisoning.