1Assistant Professor of Emergency Medicine, Kerman University of Medical Sciences, Kerman, IRAN
2Department of Emergency Medicine, Kerman University of Medical Sciences, Kerman, IRAN
3Department of Biostatistics and Epidemiology, School of Public Health, University of Medical Sciences, Kerman, Iran
*Corresponding Author: Mehdi Torabi Assistant Professor of Emergency Medicine, Department of Emergency Medicine, Kerman University of Medical Sciences, Kerman, IRAN, Tel: +98 9131992016, Fax: +98 3432474638, Email: mtorabi1390@yahoo.com, me_torabi@kmu.ac.ir
Online published on 19 January, 2018.
In the case of paraquat poisoning, determining patients’ outcome is very important. Considering the role of inflammatory and cellular injuries in the mechanism of this poisoning and finding the role of the parameters involved in these injuries can help to determine the outcome of the patients.
This historical cohort study was performed during a period of five years on patients over 16 years old, who had been poisoned with paraquat and referred to the emergency department within the first 24 hours of poisoning. Laboratory test related to the inflammation including Complete Blood Count (CBC) [White Blood Cell (WBC), the Mean Platelet Volume (MPV), and the Red cell distribution width (RDW)] and organ dysfunction scores such as Sequential Organ Failure Assessment score (SOFA score) were observed and the hospital mortality was considered as the outcome of the patients.
From 108 patients poisoned with paraquat, 61 (56.48%) were male. The mean age of the patients was 23.25±8.27 years and the hospital mortality rate was observed in 28.70% of the patients. According to the forward conditional method in multivariable analysis, the hospital mortality had a significant relationship with the leukocyte count, bicarbonate ion, and the SOFA score.
Considering inflammatory and cellular injuries, involved in paraquat poisoning, leukocytosis as a prognostic factor for inflammation, and SOFA score and acidosis as the factors related to cell injury could independently predict hospital mortality.
Paraquat, Organ dysfunction score, Leukocyte count, Bicarbonate ion
