1Assistant Professor (Ad-hoc), Department of Forensic Science, School of Life Sciences, Guru Ghasidas Vishwavidyalaya(A Central University), Bilaspur (C.G.)
2Professor, Department of Chemistry, School of Chemical Sciences, Dr. H S Gour University(A Central University), Sagar, (M.P.)
*Corresponding author: Dr. Sudhir Yadav Assistant Professor (Adhoc), Department of Forensic Science, School of Life Sciences, Guru Ghasidas Vishwavidyalaya(A Central University), Bilaspur (C.G.),. E-mail: sudhirforensic@gmail.com, Mob. No. +918889402569
Online published on 5 May, 2018.
Toxicological studies of rare-earth elements suffered from the fact that they were contaminated with other similar elements making interpretation of the results difficult. They have a low acute toxicity with LD50’s ranging from 315–585 mg/kg with numerous species. The major symptoms of acute toxicity are ataxia, laboured respiration, walking on the toes with arched back and sedation and the death rate peaking between 48 and 96 hours. Chronic intra venous injections of these elements in animal model may causes degeneration of the spleen and produces yellow atrophy and central lobular necrosis of the liver. The animals when exposed to a mixture with high fluoride content, showed acute transient chemical pneumonitis, sub acute bronchitis and bronchiolitis, focal hypertrophic emphysema and regional bronchiolar structuring. It is not surprising that biological activity is observed in a number of calcium enzymes and has been demonstrated to be good substitutes for calcium in assays of Bacillus subtitles amylase of trypsinogen to tyrosine conversion. In the present article by keeping above facts in mind the author has discuss the Lanthanide toxicity and various biological activities associated with it from reading secondary data sources i.e. e-books, research publications and various toxicological reports etc.
Lanthanides, Rare earth elements, Toxicity, Biological Activity etc
