Variations in the Physico-Chemical Parameters of Thio-Barbiturate Derivatives

The barbiturates have the ability to release certain nerve cells from the inhibitory influence of certain other cells in the brain leading to mental, emotional and behavioral changes. This action possibly accounts for the emotional instability and sometime aggressive behavior of barbiturate abuses. Barbiturates are known to have toxic activities on the body and are also known to affect the metabolic activities. The mechanisms of the processes are partially known. One of the major paths of their toxic behavior is to undergo competition with biologically important metals like Ca (II) and Mg(II) in the body. The intervention of computer in field of chemistry and in the field of mechanistic approach has helped a chemist to presume and derive relationship between specific molecular model and structural and behavior characteristics of a molecule, so as to use it as a probable drug. Finally, all barbiturates have been observed to be more or less affected by body metabolism and are thus fundamentally changed in their structure. Therefore, in this article author has stated that it is desirable to take an interest in the metabolites of barbiturates, which are often present in larger amounts than the original substance. It is also necessary to know the fate of barbiturates in the body to be able to evaluate the chemical results.