Maternal and Fetal Outcome in Patients with History of Polycystic Ovary Syndrome

PCOS among women at childbearing age is the most common endocrine disorder. Women with PCOS usually suffer from infertility, but when they conceive, there might be different complications during pregnancy, delivery, or postpartum on both the mother and the newborn that need to be discussed.

This study conducted to identify the maternal and neonatal multiple outcomes of polycystic ovarian syndrome.

A hospital based prospective cohort study was carried out in Salah Al-Din general hospital between 1st of Feb 2018 and 31st of Aug 2018. Two groups (PCOS women and Non PCOS women) were recruited for this study. Sample size was calculated by using Epitools epidemiological calculator depending on national figure of polycystic ovarian syndrome with adding an extra 10% to cover questionnaire errors; the total sample size will be 50 for each group of the study. Data collected using a special questionnaire conducted for the purpose of the study, and an appropriate statistical analysis using appropriate tests was conducted.

A total of 100 pregnant women were participated in this study and divided into two groups, polycystic and non-polycystic women. Majority (88%) of polycystic women shows typical ultrasound picture of polycystic ovary, of which 86% required assisted reproductive technology to get pregnant. Multiple outcomes found to be significantly higher among polycystic pregnant women than non-polycystic pregnant women. these outcomes includes gestational diabetes (P value = 0.0061, RR= 16.o, 95% CI =2.2–116.1), preeclampsia (P value = 0.0023, RR=2.6, 95% CI =1.4–4.8), cesarean delivery (P value= <0.0001), premature baby (P value = 0.009, RR= 14.0, 95% CI = 1.9–102.4), and neonatal intensive care unit admission (P value = < 0.0001, RR= 4.1, 95% CI=2.2–7.5).

Multiple outcomes are significantly associated with PCOS that may affect the health of mother and newborn infant. Findings which are consistent with other published studies findings.