Indian Journal of Forensic Medicine & Toxicology
  • Year: 2019
  • Volume: 13
  • Issue: 4

Biochemical Study of the Protective Effect of Vitamin C and Radish on Gentamicin-Induced Nephrotoxicity in Rats

  • Author:
  • Murooj Luai Majeed Al-Timimi1,, Ekhlas Sabah Hassan1, Rana Talib Al-Nafakh1, Shaymaa Abdul Lteef Alfadhul1, Ammar R. Mohammad1
  • Total Page Count: 5
  • Page Number: 424 to 428

1Department of Pharmacology, Faculty of Medicine, University of Kufa, Najaf, Iraq

*Corresponding author: Dr. Murooj Luai Majeed Altimimi, Department of Pharmacology, Faculty of Medicine, University of Kufa, Najaf, Iraq, Telephone: 00-964-7719814019, Email: muroojaltimimi2019@gmail.com

Online published on 27 November, 2019.

Abstract

Gentamicin is an aminoglycoside antibiotic used for treatment of serious gram-negative bacterial infections.

To investigate possible therapeutic effects of vitamin C and radish juice on gentamicin-induced nephrotoxicity in a rat model.

Thirty sexually mature male Sprague-Dawley rats were included in this study, divided randomly into 6 groups, each one included 5 rats. group 1 received saline & considered as control group, group 2 received vitamin C, group 3 received radish juice, group 4 received gentamicin, group 5 received gentamicin + vitamin C and group 6 received gentamicin + radish juice for five days. After treatment, blood samples were collected from animals for measuring of blood urea, serum creatinine and C-reactive protein.

Gentamicin cause significant elevation in blood urea (p< 0.001), serum creatinine (p< 0.001) and C-reactive protein (p< 0.001). vitamin C and radish juice cause significant reduction in blood urea (p< 0.001), serum creatinine (p< 0.001) and C-reactive protein (p< 0.001) when co administered with gentamicin treatment.

The toxic effects of gentamicin on kidney could be ameliorated by vitamin C and radish co administration & they can act as nephroprotective.

Keywords

Vitamin C, Radish, Gentamicin, Induced Nephrotoxicity, Rats