1Department of Pharmacology, Faculty of Medicine, University of Kufa, Najaf, Iraq
Gentamicin is an aminoglycoside antibiotic used for treatment of serious gram-negative bacterial infections.
To investigate possible therapeutic effects of vitamin C and radish juice on gentamicin-induced nephrotoxicity in a rat model.
Thirty sexually mature male Sprague-Dawley rats were included in this study, divided randomly into 6 groups, each one included 5 rats. group 1 received saline & considered as control group, group 2 received vitamin C, group 3 received radish juice, group 4 received gentamicin, group 5 received gentamicin + vitamin C and group 6 received gentamicin + radish juice for five days. After treatment, blood samples were collected from animals for measuring of blood urea, serum creatinine and C-reactive protein.
Gentamicin cause significant elevation in blood urea (p< 0.001), serum creatinine (p< 0.001) and C-reactive protein (p< 0.001). vitamin C and radish juice cause significant reduction in blood urea (p< 0.001), serum creatinine (p< 0.001) and C-reactive protein (p< 0.001) when co administered with gentamicin treatment.
The toxic effects of gentamicin on kidney could be ameliorated by vitamin C and radish co administration & they can act as nephroprotective.
Vitamin C, Radish, Gentamicin, Induced Nephrotoxicity, Rats
