Indian Journal of Forensic Medicine & Toxicology

The aim of the study was to determine the protective effect for the water extract of the leaves of the rosemary plant and vitamin E in reducing the oxidative stress induced by cholesterol and the activation of antioxidants in New Zealand white rabbits.

A total of 24 rabbits were distributed randomly to 4 equal groups 1 control, rabbits fed a diet rich in cholesterol (1% g/kg) and 3 treated groups (2nd group fed diet supplemented with rosemary extract 50 g/kg of animal weight, 3^rd group fed diet supplemented with 50 mg/kg of Vitamin E, while 4^th group fed diet supplemented with a mixture of vit E, for 30 days. Blood samples were taken for laboratory tests.

The results showed that in the second, third and fourth groups showed a significant decrease at level(p≤0.01) in the concentration of total cholesterol, triglycerides, high-density lipoproteins, lipoproteins, low density, lipid concentration, and very low density, comparative with cholesterol control group while showed glutathione levels were increased (p≤0.01) with 3treated groups, while malondialdehyde was obviously decreased compared with the cholesterol control group..

We conclude from the above that the studied transactions have a preventive role against the negative effect of excessive increase in the level of harmful fats on physiological and biochemical variables.