Indian Journal of Forensic Medicine & Toxicology

This research was designed to know the effect of the mycotoxin produces by the fungal species Aspergillus Niger, which is the aflatoxins on the experimental animals (albino male rats) to investigate its effect on some biochemical indicators, and some of histological sides of organs tissue.

The experiments included (12) animals divided to two groups, (6) animals for each one. The first group considered as control group which was given the water and nutrients as a normal conditions. The second group was given 5 ml as a single dose of Aspergillus Niger after the period of starvation for 3 days. The period of experiment extend for 10 days, then the animals were sacrificed.

The biochemical parameters were: liver function test included (AST, ALT, GGT), total proteins, and serum glucose). The organs were tested for the tissues change are(liver, kidney, and spleen). The results of the current study showed a significant differences in liver function tests which are increase in the treatment group (p ≤0.05) comparative to control group, there was significant decrease of total protein, and increase of S. glucose in the treatment group comparative to the control group.

The histological examination showed many change of the organs tissues resulting from the poisoning effect of aflatoxins produced by Aspergillus Niger.