Antimicrobial Activity and Molecular Modeling Study of Schiff Base Derived from Sulfamerazine

Condensation of 4-amino-N-(4-methylpyrimidin-2-yl)benzene sulfonamide (Sulphamerazine Drug) with 1, 3-Benzodioxole-5-carbaldehyde (Piperonal)yielded Schiff base derivative in good yield. Spectroscopic characterization such as, IR and NMR of synthesized compound have been obtained by using nuclear magnetic resonance 600 MHz. The synthesized compound was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus and klebsella pneumonia and fungicidal activity against Candida albicans, Candida trobicalis, Candida krusi, Aspergillus fumigatus and Aspergillus niger. A new compound exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions.