Evaluation of Oxidative Stress Status: Total Antioxidant Ratio in Serum of Patients with Metastasis and Non-metastasis Lung Cancer in Babylon Province

Oxidative stress has the critical role in the initiation and progression of any type of cancers through cellular damage. Malignant lungs tumor characterized by uncontrolled cell growth in tissues of the one or both lungs. The tumor growth is transfer from one or both lung to separating to other parts in human body. Peroxidation of membrane lipids, increase membrane fluidity and permeability with loss of its integrity that leads to cell damage has been promote by free radicals.

The present study was included three groups, 30 patients with metastasis lung cancer(MLC), 30 patients with non-metastasis cancer of lung(NMLC) whom receiving adjuvant treatment with chemotherapy in tumors center in Merjan Hospital in Babylon province, and 30 subjects as healthy control group. We investigate TAOS, MDA, UA, and trace elements copper(Cu), Zinc(Zn), and iron (Fe⁺²). All parameters including in this study were done by using colorimetric methods.

The results of this study showing significant decreasing (p-value < 0.05)in TAOS, UA, Zn, and Fe in MLC group comparing to NMLC and control group. The results show significantly increase in MDA and Cu in serum of MLC compare to NMLC and control groups. In conclusion the lack of antioxidant parameters may be promoting the risk of metastasis lung cancer.