Effects of Ethanolic Moringa Oleifera Extract on Melatonin, Liver and Kidney Function Tests in Alloxan-Induced Diabetic Rats

Moringa oleifera Lam. contains many active ingredients with nutritional and medicinal values. The aims of this study were to determine the effect of ethanolic moringa oleifera extract on glucose, melatonin, lipid profile, liver, and kidney function in alloxan induced diabetes Induced Diabetes in rats. Diabetes was induced in male Wistar rats by single intra peritoneal injection of alloxan (150 mg/kg b. wt.).The diabetic rats were administered orally with EMOE at two different doses (250 and 500 mg/kg b. wt./day) for 60 days. The alloxan treated control rats showed a significant increase in glucose (BS), total cholesterol (STC), triglycerides (STG), low density lipoprotein cholesterol (LDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatases (ALP), urea creatinine with a concomitant decrease in serum melatonin, lactate dehydrogenase (LDH), and high density lipoprotein cholesterol (HDL).Oral administration of MOLEt (250 and 500 mg/kg b. wt./day) for 60 days showed significant reduction in BS, STC, STG, LDL, ALP, ALT, AST and LDH, urea creatinine levels and an elevation in serum melatonin, LDH, and HDL levels in diabetic group as compared with control group.