Immunohistochemical Expression of TGF-β1 and Ki-67 in a Paraffin-Embedded Section of Breast Cancer Tissue

We studied laboratory and medical archives during the year 2017 for 43 female patients with ages ranged between 25 and 70 years who had been primary malignant breast cancer (BC) and operated for that. We study the TGF-β 1 and Ki-67 Immunohistochemical (IHC) expression in paraffin-embedded section of BC tissue of those patients. Then we classified the patients result according to the patients ages (premenopausal, postmenopausal), size of the BC tumor (T1-T4 lymph node metastases status ((No-N3) and distant metastases (M0–1) We detected there was high expression rate of TGF-β1 & Ki67 in the BC tissue samples from patients with age < 50years (pre-menopausal age), when it compared to patients whose age ≥ 50years (postmenopausal) Also statistically significant positive association noticed between TGF-β1 & Ki67 IHC expression with the size of BC (T1-T4), lymph node(s) metastases (N0-N3) and distance metastases (M0-M1).