1Department of Biology, College of Science, University of Basrah, Basrah, Iraq
The study was designed to evaluate the influence of induce Osteoarthritis (OA) on knee joint of experimental model and looking on (OA) effect as local and systemic immune response in addition to the possible role of Vitamin (D3) as a protective and repairing agent against (OA) complications. The results of pro-inflammatory cytokines, the data showed that there was a highly significant elevation in IL-6 level of OA induced rats in comparison with the control group. Recorded data indicated that there was a highly significant increasing (P ≤ 0.0001) in IL-6 level of OA induced rats in comparison with the treated rats. Results also demonstrated that there was an increasing in serum levels of TNF-α in OA induced in comparison with control rats(0.008) with a highly significant differences (P ≤ 0.0001). Statistical analysis revealed a highly significant (P ≤ 0.0001) heightening of TNF-α in OA induced in comparable with treated rats. the serum level of TNF-α in treated rats was also more than those of control rats with a no significant differences (P ≤ 0.099). The study determined the level of complement (C3)
Osteoarthritis, OA, C3, Pro-inflammatory cytokines, complement, papain, inflammatory response, systemic inflammatory response
