Nephrotoxic Effect of Antipsychotic Drug Risperidone: Protective Role Extract of Urtica dioica leaf in Male Stressed Rats

This research was designed to investigate the ameliorative effect of Urtica dioica leaf extract on the kidney function against Risperidone. Thirty adult male rats were randomly divided to 3 equal group and handles as follows for 4^th weeks: control group were administered tap water group G1; group G2 rats of this group had been administered risperidone 2 mg/kg orally only; group G3 rats of this group had been administered risperidone 2 mg/kg orally plus ethanolic extract of Urtica dioica (100 mg/kg). Blood sample were obtained at 15 and 30 days of the experiments for estimation of serum uric acid concentration, serum urea nitrogen concentration, serum creatinine concentration, serum peroxynitrite concentration. Significant increases in estimated parameters in group G2 (risperidone treated group). On the other hand, the results showed the beneficial effects of Urtica dioica leaf extract to improvement the previous parameters against risperidone (G3), through a significant decrease in concentrations. Histological section show atrophy and acute necrosis in renal tubules in group G2, while no clear pathological lesion in G3 group. Therefore, it could be conclude that Urtica dioica exert a protective action to alleviating the oxidative stress induced by risperidone stressed rats.