Bioactive Wood Potential (Caesalpinia sappan L.) in The Proliferation of Wistar Rats in Infection Salmonella Typhimurium

The purpose of this study was to determine the bioactive potential of secang (Caesalpinia sappan L.) wood against lymphocyte proliferation of wistar rats infected with Salmonella typhimurium. Bioactive secang wood (Caesalpinia sappan L.) has an effect, among others, as an antibacterial. Salmonella typhimurium is one of the bacteria that can cause gastroenteritis. This research was a laboratory experimental research using wistar rats which were divided into 6 groups, P0 group (1, 2, 3) is a positive control group. The P1 treatment group was given secang wood extract with a dose of 2x0.20 ml/day, P2 was given 2x0.50 ml/day, P3 was given 2x1ml/day for 2 weeks. Then wistar rats infected with Salmonella typhimurium as much as 3x10⁸ CFU/ml Mc Farland on day 13. It was incubated for 24 hours, followed by counting lymphoblasts in 200 cells on day 14. The results of Kruskal Wallis test showed no difference between the treatment group and the control group (p = 0.035). There was a significant increase in the number of lymphoblasts in the treatment group (p = 0.001) with the control group. The administration of secang wood extract can increase lymphocyte proliferation of wistar rats infected with Salmonella typhimurium.