Anticonvulsant Induced Osteomalacia in Ghaziabad, Uttar Pradesh

Antiepileptic medications encompass a wide range of drugs including anticonvulsants, benzodiazepines, enzyme inducers or inhibitors, with a variety of effects, including induction of cytochrome P450 and other enzyme, which may lead to catabolism of vitamin D and hypocalcaemia and other effects that may significantly affect the risk for osteomalacia. With the current estimate of 50 million people worldwide with epilepsy together with the rapid increase in utilization of these medications for other indications, bone disease associated with the use of antiepileptic medications is emerging as a serious health threat for millions of people. Our results indicate that the prevalence of vitamin D deficiency in epilepsy patients under AEDs treatment is high, especially under polythearpy.Thus it is suggested that routine monitoring of serum 25-OH vitamin D and vitamin D supplementation on an individual basis should be considered.