Cannabis and cannabis resins contain the substance “9-tetrahydrocannabinol (THC). The plant and drug are both regulated by the Drug Enforcement Administration (DEA) of Jordan. The regulations require testing for THC and its metabolites, which can be found in urine. 11-nor-9-carboxy-”9-THC, also known as THC-COOH, is the primary urinary metabolite of THC.
In this study, a method for confirmation analysis of large number of urine samples previously screened positive for THC using solid-phase extraction (SPE) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis is developed. The results of the analysis of standard reference material and actual samples are presented and discussed. The developed method is sensitive enough to assess relevant THC-COOH levels in human urine for forensic investigations.
SPE, GC-MS, THC-COOH, Urine
