Effect of Smoking on Plasma Homocysteine Level in Some Libyans as a Risk Factor for Cardiovascular Disease

Hyperhomocysteinmia is an independent risk factor for arteriosclerosis, recurrent thromboembolic complications and osteoporosis. Hyperhomocysteinemia may result from deficiency of folate, vitamin B-6 or vitamin B-12. Accordingly homocysteine level is highly influenced by many factors affecting individual life style such as age, sex, smoking and many other factors affected by environmental conditions. Many studies have carried out on homocysteine level in some countries in order to reach an indicative value for future cardiac problems in individuals and to undertake prophylactic measures.

This study was designed to see the effect of age, sex and smoking on fasting plasma homocystein (F-HCYST) levels in some Libyan Benghazi Citizens.

of 100 adults volunteers (50 males and 50 females) included active smokers, passive smokers and control groups were chosen as a representative samples for this study. Levels of F- HCYST was measured in relation to age, sex, and smoking by using HPLC Technique.

The F-HCYST levels were higher in males than that in females. According to age the higher F-HCYST levels were found in (30–39 years) and (> 60 years) age groups. As regard to smoking, the levels of F-HCYST were higher in passive smokers of females than in passive smokers of males.

There is increased level of plasma homocysteine in relation to specific age groups, male cases, and the effect of smoking in Libyan population. A preventive measure has to be undertaken.