Indian Journal of Forensic Medicine & Toxicology
  • Year: 2013
  • Volume: 7
  • Issue: 1

Pulmonary Responses of Manufactured Ultrafine Aluminum Oxide Particles Upon Repeated Exposure by Inhalation in Rats

  • Author:
  • P.V. Rajsekhar1, G. Selvam2, A Goparaju3, P. Balakrishna Murthy4, P. Neelakanta Reddy5
  • Total Page Count: 34
  • Page Number: 254 to 287

1M.Sc Biochemistry, Research Scholar, IIBAT, Padappai,

2M.V.Sc. Pathology, Pathologist, IIBAT, Padappai, Tamil Nadu,

3M. Sc Statistics Statistician, IIBAT, Padappai, Tamil Nadu,

4Ph.D, D.Sc, Director, IIBAT, Padappai, Tamil Nadu,

5Head, Bioorganic Chemistry laboratory, CLRI, Chennai

Online published on 21 February, 2013.

Abstract

The aim of this study is to evaluate the pulmonary effects of manufactured ultra fine (10 nm) aluminum oxide particles (UFAOP) upon repeated exposure by inhalation. Rats were exposed with UFAOP in nose-only inhalation chambers at concentrations of 0, 50, 100, and 160 mg/m3 for 6h per day on 5 days. Bronchoalveolar lavage analysis showed pulmonary inflammation and cytotoxicity. Histopathology of lungs showed particle induced cytotoxicity and inflammation characterized by mononuclear inflammatory cell infiltration. Lung burden data showed less percentage of clearance and higher biological half time for UFAOP. Based on our results we conclude that repeated inhalation exposure of UFAOP induced concentration dependant toxicity to lungs of rats at different time points of post exposure.

Keywords

UFAOP Inhalation Inflammation Nanoparticles