Antihyperglycaemic and antioxidant effects of broccoli extract, n-butanol in STZ-induced diabetic rats

This research was aimed at investigating the beneficial effects of broccoli (Brassica olearacea) on lipid peroxidation (LPO) and the antioxidant status of streptozotocin-induced diabetic rats. Four classes were allocated to thirty-two mature male rats of either non-diabetic and intake integrated feed per 28 days or three diabetic categories also and intake integrated feed per 28 days. Streptozotocin single injection diabetes blood glucose rats obtained 60 mg/kg bw, ip. Diabetic classes (II, III and IV) were drenched for 28 days including water, n-butanol extract and intake integrated feed per 28 days (60 mg/kg bw) and insulin injection (4 IU/animal). Weight gain was observed on day 29 and male rats were sacrificed, contained alanine aminotransferase, aminotransferase aspartate, catalase enzyme, superoxide dismutaseenzyme, glutathione (GSH)-transferaseenzyme, peroxidaseenzyme, reductaseenzyme, melondialdehyde and glutathioneenzyme. Diabetic rats (D) showed increased blood weight gain. There was increased ALT activity, SOD activity, CAT activity, GSH-transferase concentration and GSH-reductase concentration but still normal AST activity function was significantly decreased. Team (III), band (IV) maintained normal blood glucose. There was increased weight gain and regulated most activity of the antioxidant enzymes. N-butanol extract from celery seed also has an important role to play in alleviating complications caused by celery seed.