Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001.
A study was conducted to assess the effect of free radical damage by lipid peroxidation and super oxide dismutase activity in the heart tissue at maximum tolerable dose (MTD) of Rosuvastatin and Thiazolidinedions (Rosiglitazone and Pioglitazone) after oral administration in Sprague Dawley male rats for 28 days. Rosiglitazone and Pioglitazone caused increase in production of free radicals and reduced the super oxide dismutase activity in heart tissue. While Rosuvastatin alone and in combination with Rosiglitazone did not alter super oxide dismutase activity in heart. Rosiglitazone and Pioglitazone single and in combination caused relative increased in heart weight. These changes were associated with cardiac hypertrophy but no relative histopathological changes were observed during microscopy. Overall findings were suggestive of protective role of Rosuvastatin in heart.
Rosuvastatin, Thiazolidinediones, Oxidative stress, Heart, Sprague-Dawley rat
