Indian Journal of Field Veterinarians (The)
Open Access
  • Year: 2010
  • Volume: 6
  • Issue: 2

Effect of non-steroidal anti-inflammatory agents on plasma protein, platelets and coagulation time in rats

  • Author:
  • K. S. Misraulia, P. Kaskhedikar

Department of Veterinary Medicine College of Veterinary Science and A. H., Mhow (M.P.).

Abstract

A study was conducted on rats to evaluate the effect of aspirin, diclofenac sodium, flurbiprofen, piroxicam, nimesulide, trysin-chymotrypsin and serratiopeptidase on certain haematological parameters viz. plasma protein concentration, platelet count and coagulation time. The plasma protein concentration and platelet count was significantly (P<0.01) decreased, while the coagulation time was significantly (P<0.01) increased in all the test groups, except nimesulide, trypsin-chymotrysin and serratiopeptidase - treated groups as compared to the control.

Keywords

NSAIDs, Plasma Protein, Platelets, Coagulation time, Rats