Department of Veterinary Microbiology, College of Veterinary Science and A.H.M.P.P.C.V.V., Jabalpur, M.P.-482001, India
Online published on 31 October, 2013.
Lytic bacteriophages were evaluated for therapeutic activity against antibiotic resistant pathogenic bacteria. Twelve animals affected with chronic septic wounds were selected in therapeutic trial. These animals were subjected to topical application of phage cocktail. In the experimental animals ‘cocktail’ of phage lysate was applied topically over the wound as single dose. Gradual reduction in the swelling and discharge was observed and wounds completely subsided in almost in all the cases at 10th day after the phage application. There was no organism found at 5th day in any case after the application of Phage Lysate. Ten animals out of twelve completely recovered. Response to phage treatment in the chronic wounds in the present clinical trial was highly encouraging and the therapy is very effective and economic as compared to existing antibiotic therapy.
Phage Lysate, Phage Cocktail, Chronic Septic Wounds, Multiple Drug Resistance, Plaque Forming Unite
