The present study was undertaken to understand the association of SNP 63(rs5030952) of the CAPN 10 gene with the condition. All statistical tests based on PRISMA and PROSPERO were performed on R studio (4.2.3). The pooled odds ratio (OR) estimates did not reveal any significant association between polymorphism at the SNP 63 locus of the CAPN 10 gene and T2DM under both the Common Effects Model (CEM) and Random Effects Model (REM). Further, subgroup analysis also did not reveal any significant OR implying that the SNP 63 polymorphism does not exhibit different effects in different ethnic groups. Therefore, it is concluded that polymorphism at the SNP63 locus of the CAPN 10 gene alone has no role to play in the etiology of T2DM.
Ageing, T2DM, CAPN 10 gene, SNP polymorphisms, SNP 63, Case-control association studies, Meta-analysis
