1Laboratory for Molecular Reproduction and Genetics, Departmentof Anatomy, All India Institute of Medical Science (AIIMS), New Delhi, 110 029
School of Biotechnology, SMVDU, Katra, 182 320, J&K
*Corresponding author's e-mail: kumar.rakesh@smvdu.ac.in
Online published on 18 January, 2019.
Assisted reproductive techniques is specially a boon for severe male factor infertility with non-obstructive azoospermia (NOAZ) and severe oligospermia (<5 million/ml). To study the unusual pericentric inversion in a recurrent ICSI failure case, cytogenetic analysis was done from peripheral blood lymphocytes. Semen analysis revealed that the man had Oligoasthenoteratozoospermia with sperm count of 0.9 million/ml. A karyogram revealed pericentromeric inversion of Chromosome 7. It could be accommodated on models that location of the breakpoint harbours critical genes for spermatogenesis (swm, swm2 and STAG3). Pericentromeric Inversion for chromosome 7 is a rare finding. It may be the etiopathogenic for partial spermatogenetic arrest and recurrent ICSI failure. The children born to such couples must also be analyzed and kept under observation for any clinical indications.
ICSI, inversion, oligoasthenoteratozoo-spermia, primary infertility, swm, CFTR
