Biphasic Response of the Ions after Lambda Cyhalothrin Toxication in Albino Rats

Chronic exposure of unaware individuals to low doses of synthetic pyrethroids consequently results in undesirable effects. Lambda cyhalothrin (LC) now represent an important indoor and environmental toxin which was earlier regarded as safe for humans. Biochemical biomarkers are used for risk assessment and to identify the incidence and effects of LC on mammalian body. The current work was carried out to study lambda cyhalothrin interaction with blood ions of male albino rats. Effect of Lambda cyhalothrin on blood elements (iron, inorganic phosphorus and calcium) were evaluated in blood serum of albino rats. The LD₅₀ of LC was calculated using log-dose probit analysis. For acute dose one third of LD₅₀ was given once while for subacute it was divided for 7, 14 and 21 days. Indicate the biphasic response of iron and calcium ions after LC toxication as ions increases significantly at low dose but decreases at higher subacute dose. Whereas inorganic phosphorus shows marginal increase after dosing of LC in albino rats. Lambda cyhalothrin alters the ion metabolism and shows marginal effect on albino rats and therefore may pose threat to animals and human beings if used discriminately in future.