1Officer in-charge, Faculty of Allied Health Sciences, Shree Guru Gobind Singh Tricentenary University, Bhudera, Gurgoan, Haryana
2Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, New Delhi
3Associate Professor, Department of Physiology, Shree Guru Gobind Singh Tricentenary University, Budhera, Gurgaon, Haryana
4Associate Professor, Department of Biochemistry, Faculty of Health and Medical Sciences, Shree Guru Gobind Singh Tricentenary University, Budhera, Gurgaon, Haryana
5Vice chancellor, Shree Guru Gobind Singh Tricentenary University, Budhera, Gurgaon, Haryana
The infertility is the social stigma for an adult. It has been observed that 10–20% of total population is infertile out of which 510% population is due to the idiopathic infertility. The genetic modifications in the sequences of the Y chromosome are the main reason for the idiopathic infertility. The Y chromosome is responsible for the masculine characters in males and also it plays important role in spermatogenesis. Any alteration in the sequence of the Y genome may cause the halted spermatogenesis and thus, infertility. The most common alteration is observed as the deletion at azoospermic factor i.e. AZFa, AZFb, AZFc and AZFd regions. The mechanism of deletion and the length of the sequence deleted are the deciding factors for the azoospermic and oligospermic infertility. Beside the infertility, these deletions cause misinterpretation of forensic investigations.
Y chromosome Microdeletion, AZF, Azoospermia, Forensic, Infertility
