1Associate Professor, Department of Biochemistry, FMHS, SGT University
2Assistant Professor, Department of Biochemistry, FMHS, SGT University
3Reader, Department of OMDR, FDS, SGT University
4MBBS Student, FMHS, SGT University
*Corresponding author email id: drsanjivbansal@rediffmail.com
Online published on 3 December, 2016.
Diabetes mellitus (DM) is assuming alarming proportions in India and is one of the important causes of mortality and morbidity among non-communicable diseases. Dyslipidemia in diabetes mellitus is well known risk factor for the pathogenesis of atherosclerosis resulting in increased risk for ischemic cardiovascular disorders. In addition to conventional lipid parameters, non conventional lipid parameters which correlate better with the cardiovascular risk in diabetes need to be evaluated in the diabetic patients which can help in early screening and detection so that timely intervention can be done to control diabetes.
To evaluate the non conventional lipid parameters like small dense low density lipoprotein (sdLDL), oxidized low density lipoprotein (oxLDL), Apolioprotein A1 (Apo A1)and Apolioprotein B (Apo B) in type 2 diabetes mellitus (T2DM) and correlate their values with glycated hemoglobin (HbA1C) and conventional lipid parameters such as total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol (HDL-C).
One hundred twenty diagnosed patients of T2DM attending medicine OPDin the age group of 20–60 years were taken as cases. One hundred twenty age and gender matched healthy individuals from general population were taken as controls. Lipid profile, sdLDL, oxLDL, ApoA1, ApoB, fasting blood sugar (FBS) and HbA1C were evaluated in all the subjects. The data was recorded and analyzed on IBM SPSS system version 21. The results of cases and controls were compared by student test and chi square test. p value of <0.05 was considered significant. A p value of <0.01 was considered highly significant. All the parameters were correlated with HbA1CbySpearman's correlation coefficient.
We found significantly higher levels of sdLDL, oxLDL, ApoB, TC, TG, LDL-C, HbA1C and FBS in cases as compared to the controls. The values of ApoA1 and HDL-C were significantly lower in cases. ox LDL has shown maximum correlation with HbA1C (r=0.75) followed by Apo B (0.69) and Apo A1 (0.65).
According to our study non conventional lipid parameters appear to be better lipid marker for assessment of cardiovascular risk in T2DM patients.
OxLdL, sdLDL, Hyperglycemia, Glycated hemoglobin, Diabetes
