Child with Isoniazid Induced Psychosis: A Case Report

Isoniazid (INH) is first-line anti-tuberculosis drug and is routinely recommended as part of active and latent treatment of tuberculosis (TB) in all age groups. The adverse reactions of INH vary from mild hepatitis to severe neurological symptoms and psychosis. We report a case of drug-induced psychosis secondary to isoniazid intake in a twelve-year-old female child, who developed paranoid features after the sixth day of Isoniazid. There was no previous history of such behaviour. The child was developmentally normal and had a good scholastic performance. No history of substance abuse and no significant family history of similar illness could be elicited. All Anti tubercular drugs (ATT) were stopped and she was started on risperidone and clonazepam for management of psychotic symptoms. In 2–3 days the child was relieved of psychotic symptoms. Hence, she was started on modified ATT without Isoniazid. The child's condition improved substantially over the next 3 days.