Indian Journal of Mednodent and Allied Sciences
Open Access
  • Year: 2014
  • Volume: 2
  • Issue: 1

Design and Development of Transdermal Patches for Trandolapril

  • Author:
  • P Srikanth Reddy1,, D Saritha2, M Ravi Kumar3, K N Jayaveera4
  • Total Page Count: 7
  • Page Number: 34 to 40

1Department of Pharmaceutics, MNR College of Pharmacy, Sangareddy, Andhra Pradesh, India

2Department of Pharmaceutics, Sultan-ul-uloom College of Pharmacy, Hyderabad, India

3Department of Pharmaceutics, Geethanjali College of Pharmacy, Keesara, Hyderabad

4Chairman & CEO, Science-Tech Foundation, Bengaluru

*Corresponding Author Email: poreddysrikanthreddy@gmail.com

Online published on 15 May, 2014.

Abstract

Trandolapril is an antihypertensive agent which undergoes extensive first pass metabolism making it a possible candidate for transdermal delivery. Patches were prepared using hydroxypropylmethylcellulose, eudragit RL 100, gantrez and carbopol. The results of FTIR and DSC revealed no interaction between drug and polymers. The loss of moisture and uptake of moisture were within the limits. The formulations showed an extended release of the drug upto period of 24 hours during in vitro permeation studies and showed non-Fickian drug release. Stability of the optimized formulation was investigated as per ICH guidelines and was found to be stable with respect to drug content and in vitro permeation.

Keywords

In vitro permeation, Franz diffusion cell, Moisture uptake, Non-Fickian diffusion, Trandolapril