Misoprostol Induced Rupture of Unscarred Uterus

Misoprostol is a prostaglandin E1 analogue and very efficient uterotonic drug. The US Food and Drug Administration (FDA) has listed a range of side effects such as hyperstimulation, uterine tetany, meconium-stained amniotic fluid, uterine rupture, maternal shock, maternal death, foetal bradycardia and foetal death. Rupture of uterus during labour with hypertonic contractions is a rare complication which is potentially life threatening to both mother and foetus. Due to increased risk of hyper stimulation, meconium-stained liquor and ruptured uterus with misoprostal uterine contractility and FHR must be monitored throughout induction the ideal dosage cannot also be specified.