Keratocystic Odontogenic Tumour Admixed With Giant Cells: Case Report and Review on the Role of RANK/RANKL in its Pathogenesis

‘Odontogenic keratocyst’ (OKC) was the term coined by Philipsen in the year 1956, while Pindborg and Hansen in the year 1963 described the details of this cyst^[1,2]. OKC is renamed as keratocystic odontogenic tumour (KCOT) by WHO^[3] taking into view its aggressive and recurrent nature. OKC arises from the rests of dental lamina^[1]. It can occur anywhere in the oral cavity wherever the osseous structures are present, but most commonly in the posterior regions of the mandible^[2,4]. Since the clinical and radiological profile of OKC mimics other lesions it may affect the appropriate diagnosis. Here we report a case of aggressive OKC which affected an entire quadrant of the mandible along with the ramus.