Indian Journal of Mednodent and Allied Sciences
Open Access
  • Year: 2016
  • Volume: 4
  • Issue: 3

Evaluation of Serum Transaminases in Type 2 Diabetes Mellitus

  • Author:
  • K.V.N. Mallikarjuna Rao1,, Surya Meenakshi Pusapati2, N. Laxmana Kumar3
  • Total Page Count: 5
  • Page Number: 107 to 111

1Associate Professor, Department of Biochemistry, G.S.L Medical College, Rajamundry, Andhra Pradesh

2Student, Department of Biochemistry, G.S.L Medical College, Rajamundry, Andhra Pradesh

3Professor, Department of Biochemistry, G.S.L Medical College, Rajamundry, Andhra Pradesh

*Corresponding author email id: kotamalli@gmail.com

Online published on 4 February, 2017.

Abstract

Liver is the central hub for metabolism. Liver dysfunction in diabetes mellitus is one of the major causes of morbidity and mortality. Periodical evaluation of transaminases helps in early diagnosis of liver dysfunction.

The aim of the present study is to measure aspartate transaminase (AST) and alanine transaminase (ALT) in known cases of type 2 diabetes mellitus (T2DM) and to compare the values with matched controls.

Institutional cross-sectional observation study.

Study was done in 100 known cases of T2DM and in 30 controls. Age, AST, ALT and fasting plasma glucose (FPG) were recorded, analysed and compared between two groups.

Data was analysed using Microsoft Excel 2007 and SPSS trial version 16.0.

Significant difference between FPG, AST, ALT and age were observed between two groups (P < 0.05).

The results from our study showed that there are elevated levels of ALT and ASTs among T2DM patients when compared with normal individuals.

Keywords

Diabetes mellitus, Aspartate transaminase (AST), Alanine transaminase (ALT), Age, Fasting plasma glucose (FPG), Nephropathy, Ischaemic heart disease