International Journal of Managment, IT and Engineering
  • Year: 2013
  • Volume: 3
  • Issue: 8

Synthesis and biological study of a novel coumarin derivatives

  • Author:
  • Hussniya A Al-Difar, Mohamed N Ibrahim
  • Total Page Count: 6
  • Page Number: 229 to 234

*Chemistry Department, College of Science, Benghazi University, Benghazi, Libya

**Chemistry Department, Faculty of Education (Al-Marge), Benghazi University, Libya

Online published on 11 November, 2013.

Abstract

7-Hydroxy- 4- methyl coumarin (II) was obtained from the reaction of resorcinol (I) with ethyl acetoacetate then this compound was fused with 2- hydroxynaphthaldehyde to give compound (III).

On treatment of compound (III) through Mannich reaction with glycine and formaldehyde, it yields the final product (IV).

Both compounds (III) and (IV) were characterized by physical and spectral methods; they were also screened for their antibacterial activity.

Keywords

7- Hydroxy - 4- methyl coumarin, Resorcinol, 2-Hydroxynaphthaldehyde, Glycine, Antibacterial